Joost C M Meijers Selected Research

Thrombin

6/2022	Coagulation in gout: is there a link with disease activity?
3/2022	Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro.
1/2022	Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa.
1/2022	Iron-Driven Alterations on Red Blood Cell-Derived Microvesicles Amplify Coagulation during Hemolysis via the Intrinsic Tenase Complex.
1/2018	Coagulopathy in Zellweger spectrum disorders: a role for vitamin K.
1/2017	Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis.
1/2016	Prothrombotic state in patients with severe and prednisolone-dependent asthma.
10/2015	Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice.
10/2015	Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes.
3/2015	A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function.

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Joost C M Meijers Research Topics

Disease

29	Thrombosis (Thrombus) 11/2022 - 03/2002
21	Inflammation (Inflammations) 06/2022 - 02/2004
18	Hemorrhage 11/2022 - 11/2002
17	Sepsis (Septicemia) 06/2021 - 10/2005
14	Infections 11/2018 - 06/2003
14	Pneumonia (Pneumonitis) 11/2018 - 03/2004
10	Venous Thrombosis (Deep-Vein Thrombosis) 01/2020 - 08/2002
7	Melioidosis 09/2020 - 03/2010
7	Atherosclerosis 01/2020 - 01/2003
7	Pneumococcal Pneumonia 07/2015 - 03/2004
6	Neoplasms (Cancer) 11/2015 - 01/2003
5	Thrombophilia 01/2022 - 02/2005
4	Liver Diseases (Liver Disease) 03/2022 - 03/2010
4	Disseminated Intravascular Coagulation 06/2021 - 12/2004
4	Thrombocytopenia (Thrombopenia) 09/2020 - 01/2007
4	Asthma (Bronchial Asthma) 01/2016 - 02/2014
4	Type 2 Diabetes Mellitus (MODY) 11/2011 - 02/2004
4	Endotoxemia 12/2007 - 01/2003
3	ST Elevation Myocardial Infarction 01/2021 - 01/2016
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2021 - 08/2010
3	Hereditary Angioedemas 01/2020 - 12/2008
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020 - 09/2015
3	Hemophilia A (Haemophilia) 10/2018 - 01/2002
3	Critical Illness (Critically Ill) 04/2015 - 01/2006
3	Disease Susceptibility (Diathesis) 03/2015 - 07/2004
3	Human Influenza (Influenza) 05/2014 - 11/2006
3	Fibrosis (Cirrhosis) 01/2014 - 07/2012
3	Myocardial Infarction 04/2010 - 12/2006
3	Thrombotic Thrombocytopenic Purpura 01/2010 - 04/2008
3	Activated Protein C Resistance (APC Resistance) 07/2006 - 09/2002
3	Acute Coronary Syndrome 10/2005 - 03/2002
2	Wounds and Injuries (Trauma) 03/2022 - 11/2010
2	Fever (Fevers) 06/2021 - 01/2015
2	Angioedema 01/2020 - 04/2019
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2020 - 08/2009
2	Atherosclerotic Plaque (Atheroma) 01/2020 - 08/2014
2	Edema (Dropsy) 11/2019 - 11/2004
2	Factor XI Deficiency (Hemophilia C) 01/2019 - 07/2004
2	Pulmonary Embolism 07/2018 - 01/2010
2	Body Weight (Weight, Body) 01/2018 - 05/2007
2	Tuberculosis (Tuberculoses) 01/2017 - 04/2013

Drug/Important Bio-Agent (IBA)

29	Thrombin FDA Link 06/2022 - 03/2002
23	AnticoagulantsIBA 11/2022 - 11/2002
20	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
16	Protein CIBA 04/2017 - 02/2004
14	von Willebrand FactorIBA 09/2020 - 04/2008
12	Prothrombin (Factor II)IBA 01/2020 - 09/2002
12	Hemostatics (Antihemorrhagics)IBA 01/2017 - 01/2003
11	FibrinIBA 03/2022 - 03/2004
10	CytokinesIBA 01/2017 - 03/2008
9	fibrin fragment D (D-dimer)IBA 06/2022 - 02/2006
9	Thromboplastin (Tissue Factor)IBA 01/2019 - 01/2006
8	Carboxypeptidase B2 (Thrombin Activatable Fibrinolysis Inhibitor)IBA 10/2018 - 01/2002
7	Factor VIII (Coagulation Factor VIII)IBA 10/2018 - 07/2006
7	AntigensIBA 01/2017 - 10/2009
7	AntithrombinsIBA 03/2015 - 10/2005
6	Pharmaceutical PreparationsIBA 01/2020 - 01/2002
6	Tissue Plasminogen Activator (Alteplase)FDA Link 10/2018 - 01/2003
6	Factor XI (Plasma Thromboplastin Antecedent)IBA 01/2017 - 07/2004
6	Plasminogen InactivatorsIBA 01/2016 - 01/2006
6	Antifibrinolytic Agents (Antifibrinolytics)IBA 01/2016 - 01/2006
6	Plasminogen Activator Inhibitor 1IBA 01/2016 - 01/2009
5	Protein SIBA 09/2017 - 02/2004
5	EndotoxinsIBA 01/2017 - 07/2006
5	Fibrinolysin FDA Link 01/2016 - 01/2006
5	Heparin (Liquaemin)FDA LinkGeneric 01/2014 - 03/2002
4	Biomarkers (Surrogate Marker)IBA 06/2022 - 01/2011
4	LipopolysaccharidesIBA 06/2021 - 03/2004
4	AntibodiesIBA 01/2021 - 01/2002
4	Factor XII (Hageman Factor)IBA 11/2019 - 12/2006
4	Antisense OligonucleotidesIBA 11/2018 - 11/2010
4	ChemokinesIBA 07/2015 - 04/2009
4	lipoprotein-associated coagulation inhibitor (TFPI)IBA 07/2015 - 01/2006
4	Interleukin-6 (Interleukin 6)IBA 03/2015 - 11/2005
4	Factor VIIa (Activated Factor VII)IBA 08/2014 - 01/2006
4	recombinant FVIIa (rFVIIa)FDA Link 09/2013 - 01/2002
4	Lipoproteins (Lipoprotein)IBA 12/2008 - 06/2003
3	Factor V (Coagulation Factor V)IBA 03/2022 - 03/2015
3	Factor Xa (Coagulation Factor Xa)IBA 03/2022 - 01/2021
3	CholesterolIBA 01/2021 - 02/2004
3	Factor XIII (Coagulation Factor XIII)IBA 07/2019 - 07/2012
3	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 10/2018 - 01/2003
3	Blood Coagulation Factors (Coagulation Factor)IBA 03/2016 - 12/2006
3	Peptide Hydrolases (Proteases)FDA Link 10/2015 - 06/2011
3	Endothelial Protein C ReceptorIBA 05/2014 - 01/2013
3	Plasminogen Activators (Plasminogen Activator)IBA 04/2014 - 01/2003
3	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2014 - 03/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2013 - 04/2010
3	PlasminogenIBA 07/2010 - 01/2003
3	C-Reactive ProteinIBA 04/2010 - 04/2005
2	Complement System Proteins (Complement)IBA 01/2022 - 01/2006
2	Vitamin K FDA Link 01/2022 - 01/2018
2	Dacarbazine (DIC)FDA LinkGeneric 06/2021 - 12/2004
2	Warfarin (Coumadin)FDA LinkGeneric 01/2021 - 11/2010
2	BradykininIBA 01/2020 - 11/2019
2	MicroRNAs (MicroRNA)IBA 01/2020 - 09/2015
2	Peptides (Polypeptides)IBA 11/2019 - 11/2017
2	Factor IX (Coagulation Factor IX)FDA LinkGeneric 01/2019 - 03/2016

Therapy/Procedure

11	Therapeutics 01/2022 - 03/2002
2	Contraception (Birth Control) 01/2020 - 09/2012